大剂量甲氨蝶呤排泄延迟影响因素的研究进展

庞露,刘立民,肇丽梅

中国药学杂志 ›› 2013, Vol. 48 ›› Issue (22) : 1892-1896.

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中国药学杂志 ›› 2013, Vol. 48 ›› Issue (22) : 1892-1896. DOI: 10.11669/cpj.2013.22.002
综述

大剂量甲氨蝶呤排泄延迟影响因素的研究进展

  • 庞露,刘立民,肇丽梅*
作者信息 +

Research Progress in Influence Factors of Excretion Delay of High-dose Methotrexate

  • PANG Lu,LIU Li-min,ZHAO Li-mei*
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文章历史 +

摘要

目的 为使临床更加合理的使用甲氨蝶呤,减少不良反应发生,综述可能引起大剂量甲氨蝶呤排泄延迟的因素。方法 通过查阅近期国内外相关文献,并进行归纳整理,总结可能引起大剂量甲氨蝶呤排泄延迟的相关因素。结果与结论 患者生理状态、药物相互作用、药物代谢酶等多方面因素均可能导致甲氨蝶呤的排泄延迟,在临床应用中,应引起警惕,减少排泄延迟发生率,保证用药安全。

Abstract

In order to make a more rational clinical use of methotrexate and reduce adverse reactions, we summarize the factors that might cause excretion delay of high-dose methotrexate. METHODS After consulting relevant domestic and overseas documents published recently, we summed up some factors that might cause excretion delay of high-dose methotrexate. RESULTS AND CONCLUSION Physiological states of patients, drug interactions, drug-metabolizing enzymes, and many other factors all may lead to excretion delay of methotrexate. Therefore, we should pay attention to these factors to reduce the incidence of excretion delay and ensure safe medication in clinical application of methotrexate.

关键词

甲氨蝶呤 / 排泄延迟 / 影响因素

Key words

methotrexate / excretion delay / influence factor

引用本文

导出引用
庞露,刘立民,肇丽梅. 大剂量甲氨蝶呤排泄延迟影响因素的研究进展[J]. 中国药学杂志, 2013, 48(22): 1892-1896 https://doi.org/10.11669/cpj.2013.22.002
PANG Lu,LIU Li-min,ZHAO Li-mei. Research Progress in Influence Factors of Excretion Delay of High-dose Methotrexate[J]. Chinese Pharmaceutical Journal, 2013, 48(22): 1892-1896 https://doi.org/10.11669/cpj.2013.22.002
中图分类号: R944   

参考文献

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